10 Best Supplements For Histamine Intolerance in 2024

 #1  Probiotics- (Specialized)

Probiotics are great for building up good bacteria in the body, however, there are certain strains of bacteria that contribute to a histamine reaction. Therefore, it is important to take the right probiotic supplements formulated especially for problems with too much release of histamine or low DAO (enzyme) levels. This is the probiotic that we have used during these times of too much histamine.

#2  Histamine Blocker - (DAO Enzyme Supplements) 

This is also a great choice for helping with problematic histamine release or when DAO levels are low. This supplement contains the enzyme Diamine Oxidase from porcine kidney extract. Low levels of DAO is problematic because it is the main enzyme that keeps histamine in check.

It is important to have enough DAO to balance histamine issues. Histamine Block gives you additional enzymes to break down that histamine and help with excess histamine in the body. You take these prior to eating foods that may contribute to your histamine problem.

I recommend Histamine Block, but I do not recommend Histamine Block Plus unless it is okayed by a doctor. It is important that you consume the correct type of vitamin B which is in histamine block plus.

 #3  Natural D-Hist- Histamine Blocker

This supplement contains 5 ingredients that help the body with a healthy immune response- Quercetin, Stinging Nettles Extract, Bromelain, N-acetyl cysteine, and Vitamin C. This supplement is helpful for a sensitive immune system combating inflammation, balancing mast cell triggers from autoimmune disease, and decreasing the amount of histamine in the body. Also, N-acetyl cysteine is the amino acid which supports glutathione production, a much needed antioxidant for the body to properly repair and perform many functions.

Stinging Nettles can be a sensitive supplement for some people. I do not give D-Hist to one of my kids because she has reacted to Stinging Nettles in the past. Be mindful of this when choosing this supplement.

 #4  Quercetin

Another wonderful supplement among histamine blockers is quercetin. As this science article states, "Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators." 

This makes it a valuable tool against histamine problems. quercetin is also beneficial for allergic reactions. I have substituted this product into our routine when we did not have our regular histamine blockers on hand.

 #5  Vitamin B6

Additionally, vitamin B6 is useful for histamine problems, however, it is most important that you know which vitamin B supplement is right for you. The right amount of B6 in the body supports immune function and a healthy inflammatory response because it is a natural antihistamine and supports the body's enzymatic function for histamine degradation. 

Certain vitamin B6 supplements have ingredients which interact negatively with mold issues or with the methylation process. Some people on the other hand are able to easily take a vitamin 6 supplement. Seek professional help or do thorough research to know which is best for you.

 #6  Fish Oil- (Histamine Friendly Option)

Fish oil is a great supplement that helps with inflammation. When you have digestive issues and histamine intolerance, inflammation can become troublesome quickly. However, fish is a trigger for histamine intolerance making it a tricky supplement for some people to tolerate.

The fish oil Omne Diem uses small fish sources for their omega 3 fish oil. In turn, people with a histamine imbalance usually tolerates this fish oil much better. We have taken both this fish oil as well as Nordic Naturals.

 #7  Vitamin D

Vitamin D in the form of D3 is a must and a liquid form is even better because it will allow for better absorption. Vitamin D is best gotten from the sun, however, this is dependent on the time of the year for some places. Therefore, supplementing with this brand is a good choice.

Getting your vitamin D levels checked by a knowledgeable professional is highly recommended. I have someone that checks levels according to what is appropriate for the person, not according to the "new normal" based on the average levels.

 #8  Vitamin C 

Vitamin C is helpful but this is another supplement that has to be approached cautiously with high histamine levels. Although citrus fruits are a great source of vitamin C, they can trigger histamine problems.

Vitamin C supplements are helpful to add into your regimen as well as low-histamine greens such as collard greens and swiss chard. We also add camu camu powder into our shakes and foods because this is an excellent, absorbable source of vitamin C.

 #9  Digestive Enzymes

Problems with digestion will trigger histamine problems. Therefore, using digestive enzymes for gut health is a good idea to help the stomach break down a specific food. Then unnecessary inflammation may be better blocked. These are a great enzyme if you especially need help digesting fat. However, there are many useful enzymes to choose from.

 #10  Chinese Skullcap

Finally, the herb Chinese Skullcap is very beneficial in supporting histamine intolerance. This study shows how it reduced histamine release from mast cells in rats. Allergic reactions were repressed from the properties of this herb. Therefore, food intolerance and common symptoms of histamine intolerance is helped with the use of Chinese Skullcap.